The patients, who all recovered after isolation and treatment, were given trial courses of two different antiviral drugs, Brincidofovir and Tecovimat, which had previously shown potential for treating monkeypox in animals.
The team found little evidence to suggest that Brincidofovir was helpful, but instead they concluded that Tecovirimat appears to shorten the duration of monkeypox symptoms and therefore may also reduce the length of time infected patients are contagious.
Tecovimat is licensed in the United States and the European Union to treat monkeypox, but it has not yet been cleared by the UK Medicines and Health Products Regulatory Agency, according to the Daily Express.
Symptoms of Monkey Pox
Monkeypox, a rare virus similar to human smallpox, was first detected in the Democratic Republic of Congo in the 1970s, and cases have increased in West Africa over the past decade.
Symptoms of the disease include fever, headache, and rash, which start on the face and spread to the rest of the body.
Rodents are the main reservoir of the virus, but humans can catch monkeypox through close contact with infected people. The infection is usually mild and most people recover within a few weeks.
Researchers refer to dividing the stage of monkeypox infection into two periods, according to the World Health Organization website.
The first period is the invasion period (0 days and 5 days), and its signs include fever, severe headache, swollen lymph nodes, back and muscle pain, and severe weakness (loss of energy ).
In the second stage, the rash appears (within 1 to 3 days after the fever), and the different stages of appearance of the rash crystallize, which most often starts on the face and then spreads to other parts of the body. body.
The rash is most severe on the face (95% of cases) and on the palms of the hands and soles of the feet (75%).
After about 10 days, the rash develops into fluid-filled blisters and pustules that can take weeks to completely disappear.
Infection occurs due to direct contact with blood, body fluids, skin lesions or mucous fluids of infected animals.
In Africa, cases of infection caused by handling infected monkeys, Gambian giant rats or squirrels have been reported.
It is possible that the consumption of undercooked meat from infected animals is a risk factor associated with the development of chickenpox.
It can also result from transmission of the disease at the secondary level, or from person to person through secretions or contact.
The disease is transmitted primarily by respiratory particles that take the form of droplets that typically require long periods of face-to-face contact, putting family members of active cases at high risk of infection with the disease, and it is also possible for the disease to be transmitted through sexual intercourse or through the placenta.